The gene with the mutation is also called a "cancer susceptibility gene. However, if the working copy of the gene in a cell becomes damaged by a mutation, that cell can lose its growth control and become cancerous. Thus, individuals who inherit a cancer susceptibility gene have a much greater chance for developing certain cancers in their lifetime. However, not everyone with an inherited cancer susceptibility gene will develop cancer. Damaged cancer susceptibility genes can be inherited, and passed on, by men just as easily as women.
If a parent carries a cancer susceptibility gene, each of their children has a 50 percent chance of inheriting the gene, and thus the susceptibility to cancer. Each child also has a 50 percent chance of inheriting the working copy of the gene, in which case their cancer risk would be no higher than that of the general population. It should be noted that some cancer susceptibility genes only have links to cancers that may not be seen in both sexes, such as ovarian and prostate cancers. Parents of the unaffected sex can still carry and pass on these genes.
Hereditary cancers generally are not significantly different from non-hereditary cancers. Genetic Counselor. Nicole Mans, M. Daniela Martiniuc, M. Toggle navigation.
Fill out family history questionnaire here What is genetic counseling? Contact the Hereditary Cancer Program. Sacramento, CA Phone : option 7 Fax referrals : Fax clinic : Hereditary Cancer Program.
How to schedule an appointment. For self-referrals and any questions, please call us at , option 7. Some indications for meeting with a genetic counselor. Adults Diagnosis of cancer prior to age 50 More than one relative with the same or related cancers Individuals with more than one primary cancer A relative who carries a mutation for hereditary cancer Diagnosis of rare or unusual cancers in the family Diagnosis of certain cancers along with Ashkenazi Jewish ancestry Multiple precancerous colon polyps found on colonoscopy Children A parent who carries a mutation that confers cancer risk in childhood Diagnosis of specific tumors that are more likely to have an inherited basis, such as sarcomas or certain brain tumors Diagnosis of typically adult-onset cancers in childhood A child with cancer and history of delayed milestones.
What to expect at your or your child's appointment. This information helps estimate the chance that you or your family could have an inherited gene mutation that causes a higher risk of developing cancer. You may be offered genetic testing depending on your personal or family history of cancer. If so, the genetic counselor will explain the risks, benefits, limitations and implications of genetic testing so you can make an informed decision.
If testing is indicated, cost, insurance coverage and privacy considerations will be discussed. Genetic testing is typically performed by drawing one tube of blood for analysis. A follow up appointment will be scheduled with your genetic counselor to review the results. A hereditary cancer evaluation includes a detailed assessment of family history and medical records to determine the cancer risk for the patient and family.
If an inherited risk is identified, genetic testing is discussed including the benefits and limitations, costs and insurance coverage.
For those who choose to pursue testing, results are discussed in detail. For those who carry a predisposing gene change, we will discuss risk reduction strategies, management options and testing alternatives for family members. While we are ranked among the best children's hospitals in the country, it's our compassionate approach to treatment that makes us truly exceptional.
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